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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1912 1
1918 1
1920 3
1921 2
1922 5
1923 5
1924 6
1925 1
1926 1
1927 3
1928 4
1929 5
1930 7
1931 8
1932 5
1933 5
1934 2
1935 7
1936 4
1937 5
1938 7
1939 5
1940 4
1941 6
1942 8
1943 3
1944 6
1945 3
1946 18
1947 35
1948 21
1949 26
1950 22
1951 46
1952 49
1953 69
1954 81
1955 85
1956 104
1957 115
1958 142
1959 103
1960 81
1961 101
1962 118
1963 108
1964 178
1965 212
1966 424
1967 821
1968 1022
1969 1176
1970 1178
1971 1388
1972 1633
1973 1640
1974 1637
1975 3335
1976 3608
1977 3604
1978 3659
1979 4061
1980 4525
1981 4844
1982 5460
1983 6358
1984 7378
1985 7749
1986 8405
1987 9012
1988 9497
1989 11089
1990 11789
1991 12417
1992 13042
1993 13914
1994 14566
1995 15600
1996 16791
1997 17468
1998 18638
1999 19700
2000 22107
2001 23543
2002 25581
2003 28147
2004 31360
2005 35971
2006 39673
2007 43474
2008 47906
2009 51239
2010 58132
2011 65409
2012 73657
2013 80143
2014 86721
2015 92658
2016 98859
2017 107020
2018 115604
2019 124630
2020 148236
2021 182623
2022 190792
2023 189434
2024 84396

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2,057,042 results

Results by year

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Page 1
Small molecules restore azole activity against drug-tolerant and drug-resistant Candida isolates.
Alabi PE, Gautier C, Murphy TP, Gu X, Lepas M, Aimanianda V, Sello JK, Ene IV. Alabi PE, et al. mBio. 2023 Aug 31;14(4):e0047923. doi: 10.1128/mbio.00479-23. Epub 2023 Jun 16. mBio. 2023. PMID: 37326546 Free PMC article.
This screening effort led to the discovery of novel 1,4-benzodiazepines that restore fluconazole susceptibility in resistant isolates of Candida albicans, as evidenced by 100-1,000-fold potentiation of fluconazole activity. This potentiation effect was also o …
This screening effort led to the discovery of novel 1,4-benzodiazepines that restore fluconazole susceptibility in resistant isolates of Can …
Applications and perspectives of nanomaterials in novel vaccine development.
Shen Y, Hao T, Ou S, Hu C, Chen L. Shen Y, et al. Medchemcomm. 2017 Oct 17;9(2):226-238. doi: 10.1039/c7md00158d. eCollection 2018 Feb 1. Medchemcomm. 2017. PMID: 30108916 Free PMC article. Review.
Vaccines show great potential for both prophylactic and therapeutic use in infections, cancer, and other diseases. With the rapid development of bio-technologies and materials sciences, nanomaterials are playing essential roles in novel vaccine formulations and can boost a …
Vaccines show great potential for both prophylactic and therapeutic use in infections, cancer, and other diseases. With the rapid dev …
Understanding Vertical Jump Potentiation: A Deterministic Model.
Suchomel TJ, Lamont HS, Moir GL. Suchomel TJ, et al. Sports Med. 2016 Jun;46(6):809-28. doi: 10.1007/s40279-015-0466-9. Sports Med. 2016. PMID: 26712510 Review.
There are a number of factors that must be considered when designing an effective strength-power potentiation complex (SPPC) focused on vertical jump potentiation. ...Aspects of the SPPC that must be considered for vertical jump potentiation include th …
There are a number of factors that must be considered when designing an effective strength-power potentiation complex (SPPC) f …
New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance.
Klobucar K, Brown ED. Klobucar K, et al. Curr Opin Chem Biol. 2022 Feb;66:102099. doi: 10.1016/j.cbpa.2021.102099. Epub 2021 Nov 19. Curr Opin Chem Biol. 2022. PMID: 34808425 Review.
Because of the rise in antibiotic resistance and the dwindling pipeline of effective antibiotics, it is imperative to explore avenues that breathe new life into existing drugs. ...In this review, we survey chemical matter which has been shown to potentiate antibioti …
Because of the rise in antibiotic resistance and the dwindling pipeline of effective antibiotics, it is imperative to explore avenues …
Potentiating SLC transporter activity: Emerging drug discovery opportunities.
Rives ML, Javitch JA, Wickenden AD. Rives ML, et al. Biochem Pharmacol. 2017 Jul 1;135:1-11. doi: 10.1016/j.bcp.2017.02.010. Epub 2017 Feb 16. Biochem Pharmacol. 2017. PMID: 28214518 Review.
Interestingly though, although loss-of-function mutations in numerous human SLC transporters are linked to Mendelian diseases, few reports of SLC transporter activators have appeared, and only inhibitors have been advanced to clinical studies. In this commentary, we discuss sever …
Interestingly though, although loss-of-function mutations in numerous human SLC transporters are linked to Mendelian diseases, few reports o …
Antibiotic Potentiation as a Promising Strategy to Combat Macrolide Resistance in Bacterial Pathogens.
Paul D, Chawla M, Ahrodia T, Narendrakumar L, Das B. Paul D, et al. Antibiotics (Basel). 2023 Dec 11;12(12):1715. doi: 10.3390/antibiotics12121715. Antibiotics (Basel). 2023. PMID: 38136749 Free PMC article. Review.
Thus, potentiating the existing antibiotics is one of the promising approaches to tackle and minimize the impact of antimicrobial resistance (AMR). Several natural and synthetic compounds have demonstrated effectiveness in potentiating macrolide antibiotics a …
Thus, potentiating the existing antibiotics is one of the promising approaches to tackle and minimize the impact of antimicrobial res …
The Hydrophobicity and Antifungal Potentiation of Burkholdine Analogues.
Konno H, Sasaki M, Sano H, Osawa K, Nosaka K, Yano S. Konno H, et al. Molecules. 2022 Feb 10;27(4):1191. doi: 10.3390/molecules27041191. Molecules. 2022. PMID: 35208979 Free PMC article.
Although none of the synthesized peptides exhibited antifungal activity, several did potentiate the antibiotic effect of the antibiotic G418, including the Thr-bearing Bk analogue (4b) and the tartaramide-bearing Bk analogue (5b). This work exemplifies the potent …
Although none of the synthesized peptides exhibited antifungal activity, several did potentiate the antibiotic effect of the a …
Antibiotic Potentiation of Natural Products: A Promising Target to Fight Pathogenic Bacteria.
Sadeer NB, Mahomoodally MF. Sadeer NB, et al. Curr Drug Targets. 2021;22(5):555-572. doi: 10.2174/1389450121666200924113740. Curr Drug Targets. 2021. PMID: 32972338 Review.
Plant-derived compounds such as gallic acid and tannic acid are effective potentiators of various antibiotics, including novobiocin, chlorobiocin, coumermycin, fusidic acid, and rifampicin, resulting in a 4-fold increase in the potencies of these antibiotics. Severa …
Plant-derived compounds such as gallic acid and tannic acid are effective potentiators of various antibiotics, including novob …
Glutamate potentiates heterologously expressed homomeric acid-sensing ion channel 1a.
Shteinikov V, Evlanenkov K, Bolshakov K, Tikhonov D. Shteinikov V, et al. Synapse. 2022 Apr;76(5-6):e22227. doi: 10.1002/syn.22227. Epub 2022 Feb 25. Synapse. 2022. PMID: 35157787
At pH=6.5 glutamate had maximum potentiation of 87% with an EC(50) value of 0.65 mM. The mechanism of potentiation is due to a shift of pH-dependent activation to less acidic values, with 0.5 mM glutamate increasing pH(50) from 6.04 to 6.43. Due to this mechanism, A …
At pH=6.5 glutamate had maximum potentiation of 87% with an EC(50) value of 0.65 mM. The mechanism of potentiation is due to a …
Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide-gated (HCN4) channels.
Page DA, Ruben PC. Page DA, et al. J Gen Physiol. 2024 Jun 3;156(6):e202313505. doi: 10.1085/jgp.202313505. Epub 2024 Apr 23. J Gen Physiol. 2024. PMID: 38652080
HCN4 channels were expressed in HEK 293T cells, and the effect of CBD application was examined using a whole-cell patch clamp. ...We found that CBD's mechanism of action was distinct from cAMP, as CBD also potentiated apo-HCN4 channels. The addition of an exogenous …
HCN4 channels were expressed in HEK 293T cells, and the effect of CBD application was examined using a whole-cell patch clamp. ...We …
2,057,042 results
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